The FABLE Consortium’s latest position paper explores how food system management up to 2050 will significantly impact three targets (1, 3, 10) of the Kunming-Montreal Global Biodiversity Framework. It calls for transformative changes in national biodiversity strategies, urging countries to incorporate sustainable food and land use practices. Using integrated models from 22 countries, the paper highlights the critical need for reducing agricultural demand, closing yield gaps, promoting agroecological practices, and restoring land while respecting local knowledge. These actions are essential for reaching global biodiversity goals, mitigating climate change, and ensuring food security.